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  • Title: Interleukin-6 stimulates prostaglandin production by human amnion and decidual cells.
    Author: Mitchell MD, Dudley DJ, Edwin SS, Schiller SL.
    Journal: Eur J Pharmacol; 1991 Jan 03; 192(1):189-91. PubMed ID: 2040361.
    Abstract:
    The effects of interleukin-6 on prostaglandin production by cells from two key sources on intrauterine prostaglandin, i.e. amnion and decidua, have been evaluated. Interleukin-6 induced a concentration-related increase in prostaglandin production by amnion and decidual cells. The concentrations of interleukin-6 required for this stimulatory action are within the range measured in amniotic fluid of women with intrauterine infections and preterm labor. Hence, interleukin-6 may contribute to the mechanism of preterm labor under these conditions.
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