These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The role of IgA and IgA Fc receptors as anti-inflammatory agents.
    Author: Monteiro RC.
    Journal: J Clin Immunol; 2010 May; 30 Suppl 1():S61-4. PubMed ID: 20405182.
    Abstract:
    MATERIALS AND METHODS: Serum monomeric immunoglobulin A (IgA) has powerful immunomodulatory roles in its ability to suppress immune responses. Monomeric IgA acts through FcalphaRI, which plays a significant role in vivo in maintaining the integrity of immune responses by an inhibitory immunoreceptor tyrosine-based activation motif-mediated process and powerful inhibitory cellular effector mechanisms elicited by the IgA system. RESULTS: Triggering of FcalphaRI-mediated inhibitory function by Fab anti-FcalphaRI-mediated inhibitory function is able to inhibit several inflammatory and autoimmune diseases including asthma and glomerulonephritis. CONCLUSION: The use of monomeric IgA as a therapeutic tool in human inflammatory diseases may offer much potential.
    [Abstract] [Full Text] [Related] [New Search]