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  • Title: A new label-free continuous fluorometric assay for trypsin and inhibitor screening with tetraphenylethene compounds.
    Author: Xue W, Zhang G, Zhang D, Zhu D.
    Journal: Org Lett; 2010 May 21; 12(10):2274-7. PubMed ID: 20405874.
    Abstract:
    A new label-free continuous assay with the ensemble of compound 1 and Arg(6) for trypsin and inhibitor screening was successfully developed by taking advantage of the aggregation-induced emission feature of tetraphenylethene compounds. Both CLSM and DLS studies confirm the formation of the aggregation complex of compound 1 and Arg(6) and disassembly after further addition of trypsin.
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