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  • Title: [Erythropoiesis-stimulating properties of an antiserotonin drug under cytostatic treatment conditions].
    Author: Skurikhin EG, Pershina OV, Ermakova NN, Andreeva TV, Khmelevskaia ES, Borsuk OS, Dygaĭ AM.
    Journal: Eksp Klin Farmakol; 2010 Mar; 73(3):21-4. PubMed ID: 20408425.
    Abstract:
    Effect of the antiserotonin drug cyproheptadine on the erythropoiesis has been studied under conditions of the administration of cytostatics (fluoropyrimidine antimetabolite 5-fluorouracil (5-FU), alkylating agent cyclophosphane) with different mechanisms of action. It is established that the antiserotonin drug significantly accelerates regeneration of the erythroid hemopoietic branch, especially in the case of 5-FU. The depression of erythron under the conditions of cyclophosphane injections was retained. The erythropoiesis-stimulating effect of cyproheptadine is based on the restoration of the structural and functional organization of the bone marrow (formation of erythroid hemopoietic islets).
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