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  • Title: [Clinical efficacy of cefpirome against various infectious diseases in children].
    Author: Wakiguchi H, Fujieda M, Maeda A, Shimazaki Y, Ohishi N, Kido S, Takechi T, Takeda K, Maeda H, Morita H.
    Journal: Jpn J Antibiot; 1991 Feb; 44(2):241-5. PubMed ID: 2041163.
    Abstract:
    The clinical efficacy and the pharmacokinetics of cefpirome (CPR, HR 810), a new semisynthetic cephalosporin derivative, were investigated in children with various infectious diseases. CPR showed high blood peak levels, relatively long half-life and high levels in urine. Excellent clinical efficacy was obtained in 2/3 cases with pneumonia, 3/4 cases with upper respiratory infection, 2/2 cases with cutaneous and soft tissue infection and 1/1 case with urinary tract infection. The overall efficacy rate was 80%. No clinical adverse effects were observed while slightly elevated GPT and GOT, decreased platelet were detected in 4 cases without clinical problems. CPR should be an useful and safe drug in treating infectious diseases in children.
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