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  • Title: Cytotoxic nor-chamigrane and chamigrane endoperoxides from a basidiomycetous fungus.
    Author: Chokpaiboon S, Sommit D, Teerawatananond T, Muangsin N, Bunyapaiboonsri T, Pudhom K.
    Journal: J Nat Prod; 2010 May 28; 73(5):1005-7. PubMed ID: 20411928.
    Abstract:
    A new nor-chamigrane endoperoxide, merulin A (1), and two new chamigrane endoperoxides, merulins B and C (2, 3), were isolated from the culture broth extract of an endophytic fungus of Xylocarpus granatum. Their structures were elucidated on the basis of spectroscopic, mainly NMR and MS, data. X-ray crystallographic analysis confirmed the structure of 1. Compounds 1 and 3 displayed significant cytotoxicity against human breast (BT474) and colon (SW620) cancer cell lines.
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