These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Ivabradine: from molecular basis to clinical effectiveness.
    Author: Riccioni G.
    Journal: Adv Ther; 2010 Mar; 27(3):160-7. PubMed ID: 20419486.
    Abstract:
    Ivabradine (IVA) is a novel, specific, heart rate (HR)-lowering agent that acts in sinoatrial node (SAN) cells by selectively inhibiting the pacemaker If current in a dose-dependent manner by slowing the diastolic depolarization slope of SAN cells, and reducing HR at rest and during exercise with minimal effect on myocardial contractility, blood pressure, and intracardiac conduction. Many published studies have demonstrated that HR reduction with IVA is beneficial in patients with chronic stable angina. IVA has been shown to be noninferior to beta-blocker and calcium antagonist drugs in HR reduction. The specific pharmacodynamic and pharmacokinetic properties of IVA make it an important agent in the management of patients with coronary artery disease, particularly in those patients with an elevated HR. The aim of this short review is to describe the regulation of HR and If current with IVA, and some beneficial effects of this medication in patients with coronary artery disease.
    [Abstract] [Full Text] [Related] [New Search]