These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Method of modelling intracellular transport in branching neurites: application to axons and dendrites of Drosophila sensory neurons.
    Author: Kuznetsov AV.
    Journal: Comput Methods Biomech Biomed Engin; 2011 Mar; 14(3):239-51. PubMed ID: 20419522.
    Abstract:
    This paper develops a method of calculating the transport of intracellular organelles in neurons with branching neurites which is based on the Smith-Simmons equations of motor-assisted transport. The method is aimed at understanding the effects of microtubule (MT) polarity orientation in branching neurites on transport of organelles at the fundamental level. The method is applied to calculating the organelle transport in axons and dendrites of Drosophila neurons, using the map of MT orientation in such neurons developed by Stone et al. (Mol Biol Cell 19:4122-4129, 2008). The proximal dendrite is assumed to branch and form two distal dendrites. Two different MT polarity arrangements in a proximal dendrite are considered, and implications of these MT arrangements on organelle transport are analysed. It is demonstrated that the MT arrangement found in Drosophila dendrites (MTs have their minus ends out in a proximal dendrite) results in much more efficient motor-driven transport than the structure with a mixed MT orientation in proximal dendrites.
    [Abstract] [Full Text] [Related] [New Search]