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  • Title: New 2-(2-phenylethyl)chromone derivatives from the seeds of Cucumis melo L var. reticulatus.
    Author: Ibrahim SR.
    Journal: Nat Prod Commun; 2010 Mar; 5(3):403-6. PubMed ID: 20420317.
    Abstract:
    Chemical investigation of the methanolic extract of the seeds of Cucumis melo L. var. reticulatus (Cucurbitaceae) afforded three new chromone derivatives; 5,7-dihydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone 3, 5,7-dihydroxy-2-[2-(3,4-dihydroxyphenyl)ethyl]chromone 4, and 7-glucosyloxy-5-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone 6, together with three known compounds; beta-amyrin 1, beta-sitosterol 2, and beta-sitosterol-3-O-beta-glucopyranoside 5. Their structures were established by UV, IR, 1D and 2D NMR, in addition to mass spectroscopic data and comparison with literature data. The n-hexane and methanolic extracts were evaluated for their antimicrobial activity, as well as cytotoxic activity using the brine shrimp bioassay.
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