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  • Title: Senescence-related truncation and multimerization of apolipoprotein A-I in high-density lipoprotein with an elevated level of advanced glycated end products and cholesteryl ester transfer activity.
    Author: Park KH, Shin DG, Kim JR, Cho KH.
    Journal: J Gerontol A Biol Sci Med Sci; 2010 Jun; 65(6):600-10. PubMed ID: 20421239.
    Abstract:
    To compare the change in lipoprotein metabolism with aging, we analyzed the lipid and protein compositions of individual lipoprotein fractions. Healthy and nonobese elderly participants (elderly group, n = 26) had a serum lipid profile within the normal range, although slightly higher than in young participants (control group, n = 18). However, the elderly group had a twofold higher serum uric acid level and triglyceride (TG):high-density lipoprotein cholesterol ratio. The elderly group had less antioxidant ability and elevated TG content in high-density lipoprotein (HDL) with enhanced cholesteryl ester transfer activity. An elevated level of advanced glycated end products in lipoproteins and fragmentation of apoA-I were present in the elderly group, with detected lower apoA-I level and more multimerized apoA-I in HDL. The protein levels of apoA-I, apoC-III, and serum amyloid A in lipoprotein-deficient serum were increased in the elderly group.
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