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  • Title: Bifunctional catalysis: direct reductive amination of aliphatic ketones with an iridium-phosphate catalyst.
    Author: Villa-Marcos B, Li C, Mulholland KR, Hogan PJ, Xiao J.
    Journal: Molecules; 2010 Apr 08; 15(4):2453-72. PubMed ID: 20428055.
    Abstract:
    Chiral amines are one of the ubiquitous functional groups in fine chemical, pharmaceutical and agrochemical products, and the most convenient, economical, and eco-benign synthetic pathway to these amines is direct asymmetric reductive amination (DARA) of prochiral ketones. This paper shows that a wide range of aliphatic ketones can be directly aminated under hydrogenation conditions, affording chiral amines with good to excellent yields and with enantioselectivities up to 96% ee. The catalysis is effected by the cooperative action of a cationic Cp*Ir(III) complex and its phosphate counteranion.
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