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  • Title: A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity.
    Author: Su Z, Rogers SA, McCall WS, Smith AC, Ravishankar S, Mullikin T, Melander C.
    Journal: Org Biomol Chem; 2010 Jun 21; 8(12):2814-22. PubMed ID: 20428587.
    Abstract:
    A library of 4,5-disubstituted-2-aminoimidazoles was synthesized using a nitroenolate route and then screened for antibiofilm and antimicrobial activity. These compounds displayed notable biofilm dispersal and planktonic microbicidal activity against various Gram-positive and Gram-negative bacteria.
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