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  • Title: [Proteasomes and their role in transcriptional regulation].
    Author: Moiseeva TN, Mittenberg AG, Barlev NA.
    Journal: Tsitologiia; 2010; 52(3):195-203. PubMed ID: 20429296.
    Abstract:
    26S proteasome is a multisubunit protein complex that plays a pivotal role in protein degradation. Proteasome's enzymatic activities--proteolytic, ATPase/helicase and RNase--can be used in regulation of multiple cellular processes. Recent studies confirm the major role of proteasomes in transcriptional regulation. Although various post-translational modifications of proteasome subunits have been described, relatively little is known about their functional effect on regulation of proteasome-dependent gene expression. In this article, we talk about the role of proteasomes in control of gene expression and different stages of transcription.
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