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  • Title: Enhanced reactivity to malondialdehyde-modified proteins by systemic lupus erythematosus autoantibodies.
    Author: Ben Mansour R, Lassoued S, Elgaied A, Haddouk S, Marzouk S, Bahloul Z, Masmoudi H, Attia H, Aïfa MS, Fakhfakh F.
    Journal: Scand J Rheumatol; 2010 May; 39(3):247-53. PubMed ID: 20429675.
    Abstract:
    OBJECTIVE: Evaluation of the reactivity of autoantibodies of systemic lupus erythematosus (SLE) patients directed against malondialdehyde (MDA)-modified catalase, superoxide dismutase (SOD), and different Hep2 protein fractions (hydrophobic, hydrophilic, and nuclear). METHOD: Thiol groups and MDA-protein adducts were first assessed among 65 SLE patients and 60 healthy controls. Then, the reactivities of SLE immunoglobulin (Ig)G autoantibodies towards MDA-modified and unmodified proteins were compared using a standard enzyme-linked immunosorbent assay (ELISA). RESULTS: An increase in the levels of MDA-modified proteins and a decrease in the concentration of thiol groups among SLE patients (p < 0.05) were observed. IgG circulating autoantibodies in the sera of SLE patients exhibited a significant enhanced reactivity (p < 0.05) against catalase and SOD-modified proteins. The same data were observed in the different protein fractions extracted from cultured cells (p < 0.05). CONCLUSION: These data reinforce the role of oxidative stress and especially lipid peroxidation products in the progression of SLE disease.
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