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  • Title: DNA single strand-breaks in lymphocytes after metronidazole therapy.
    Author: Reitz M, Rumpf M, Knitza R.
    Journal: Arzneimittelforschung; 1991 Feb; 41(2):155-6. PubMed ID: 2043178.
    Abstract:
    DNA single strand-breaks were examined in lymphocytes of patients treated with metronidazole (CAS 443-48-1) for trichomonas vaginalis infection before, on day one, and day seven of treatment. Recommended dosage of metronidazole induces DNA single strand-breaks. Single strand-breaks were repaired after therapy. No irreversible DNA damage remains. The DNA repair mechanisms are genetically determined. Therefore a mutagenic effect of metronidazole must be discussed in patients with DNA repair defects.
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