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  • Title: Sesquiterpene lactones from Inula oculus-christi.
    Author: Mosaddegh M, Moghadam MH, Ghafari S, Naghibi F, Ostad SN, Read RW.
    Journal: Nat Prod Commun; 2010 Apr; 5(4):511-4. PubMed ID: 20433061.
    Abstract:
    Inula oculus-christi L. (Compositae) extract was chromatographed and three sesquiterpene lactones ergolide, gaillardin and pulchellin C were isolated. The structures of these compounds were determined by analysis of their spectroscopic data, and their crystal structures were defined using X-ray crystallography; the isolation of ergolide and pulchellin C is reported for the first time from this species. These three compounds were evaluated for their in vitro cytotoxic activity against MDBK, MCF7 and WEHI164 cells; ergolide and gaillardin exhibited lower and significantly different IC50 values compared with pulchellin C (p<0.001).
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