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  • Title: PTPN22 1858T allele is associated with younger age at onset of type 1 diabetes and is not related to subsequent thyroid autoimmunity.
    Author: Kordonouri O, Hartmann R, Badenhoop K, Kahles H, Ilonen J.
    Journal: Hum Immunol; 2010 Jul; 71(7):731-2. PubMed ID: 20438787.
    Abstract:
    To evaluate the prevalence of PTPN22 C1858T polymorphism in young type 1 diabetes patients with or without autoimmune thyroiditis. Genotyping was performed in 209 controls and 243 patients diagnosed with diabetes at median age of 8.6 years. Diabetes-related autoimmunity was assessed at diagnosis of the disease, while thyroid-related autoimmunity was determined at diabetes onset and at annual intervals up to 15 years of follow-up. The 1858T allele frequency was 15.2% in patients and 10.5% in controls (odds ratio 1.53, p = 0.037). 1858T positive patients were significantly younger at diagnosis of diabetes than those without this allele (p = 0.003). No association was found between C1858T polymorphism and diabetes-related autoimmunity (p = 0.173) or thyroid autoimmune disease (p = 0.321), respectively. We conclude that PTPN22 1858T allele is an independent risk factor for type 1 diabetes and associated with younger age at the onset of the disease. However, no association with concomitant thyroid autoimmunity was found.
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