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  • Title: Unusual manifestation of parathyroid carcinoma in the setting of papillary thyroid cancer.
    Author: Chaychi L, Belbruno K, Golding A, Memoli V.
    Journal: Endocr Pract; 2010; 16(4):664-8. PubMed ID: 20439239.
    Abstract:
    OBJECTIVE: To describe a rare manifestation of parathyroid carcinoma in association with papillary thyroid carcinoma. METHODS: We describe the clinical history, findings on physical examination, results of laboratory studies, imaging findings, and histopathologic features of a woman with 2 previously palpable thyroid nodules and mild hypercalcemia. RESULTS: A 79-year-old woman presented to our endocrinology clinic for reevaluation of 2 thyroid nodules and long-standing hyperparathyroidism. She initially had undergone assessment 6 years previously, at which time an intact parathyroid hormone level was 89 pg/mL (reference range, 10 to 69) and the serum calcium concentration was 10.4 mg/dL (reference range, 8.2 to 10.2) in conjunction with normal alkaline phosphatase, creatinine, and 25-hydroxyvitamin D levels. Subsequently, she was found to have multifocal papillary thyroid cancer in the right thyroid lobe and a 5-cm parathyroid carcinoma in the left side. CONCLUSION: Synchronous parathyroid and thyroid carcinomas are extremely rare. To our knowledge, our current case is the first documented patient with parathyroid carcinoma who had a clinical presentation consistent with longstanding mild adenoma in addition to synchronous papillary thyroid carcinoma.
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