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  • Title: Convenient synthesis of allylic thioethers from phosphorothioate esters and alcohols.
    Author: Robertson F, Wu J.
    Journal: Org Lett; 2010 Jun 04; 12(11):2668-71. PubMed ID: 20441179.
    Abstract:
    The synthesis of allylic thioethers arising from the reaction between phosphorothioate esters and alcohols is described. The synthesis is accomplished in one step by the addition of an exogenous alkoxide to the corresponding allylic phosphorothioate ester. It is demonstrated that this process is amenable to various functional groups and a wide variety of heterocycles. In contrast to conventional methods for thioether synthesis, no malodorous sulfur compounds such as thioacetic acid or thiols are required.
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