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  • Title: Release of copper and indomethacin from intrauterine devices immersed in simulated uterine fluid.
    Author: Zhou X, Li Y, Jiang X, Qiu L, Liu J.
    Journal: Eur J Contracept Reprod Health Care; 2010 Jun; 15(3):205-12. PubMed ID: 20441407.
    Abstract:
    OBJECTIVES: To study the release of cupric ions and indomethacin from copper-bearing intrauterine devices (Cu-IUDs) and to assess the influence of their surface area of copper and the pH of the test medium on the release of cupric ions. METHODS: Cu-IUDs were incubated in simulated uterine fluid (SUF). The in vitro release of cupric ions and indomethacin was determined by means of a flame atomic absorption spectrometer and a UV 752 spectrophotometer, respectively, over a period of 220 days. The effect of indomethacin on the pH of the SUF was monitored during the cupric ions release study. RESULTS: The Cu-IUDs released cupric ions in vitro according to a biphasic pattern. After an initial burst release, the rate slowed down and then became steady. The release of indomethacin from two medicated Cu-IUDs was biphasic and, in both cases, in accordance with the in vitro dissolution model of the drug. The surface area of copper of Cu-IUDs and the pH change induced by indomethacin incorporated in their frame affected the release rate of copper (p < 0.05). CONCLUSION: The surface area of the copper and the pH of the test medium modulate the in vitro release of cupric ions from Cu-IUDs.
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