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  • Title: Phenotypic modification of SV40-transformed hamster lymphoid cells in vivo.
    Author: Lin PS, Butterfield CE, Wallach FH.
    Journal: Cell Biol Int Rep; 1978 Jan; 2(1):11-8. PubMed ID: 204420.
    Abstract:
    Explants of simian virus 40 (SV40)-induced lymphoid tumors yield SV40-T-antigen-positive derivatives that differ from GD248 lymphocytes propagated in suspension culture, (or in vivo), in the following respects: polygonal shape, adhesion to culture substrates in vitro, phagocytic capacity, lack of immunoglobulin and a chromosome complement at least twice that of GD248 lymphocytes. When GD-248 lymphocytes are propagated as suspension in vitro, no such adherent variants can be detected. However, sequential in vivo passage of GD248 lymphocytes obtained from the suspension-culture lines also yield adherent cell lines upon explanation in vitro. Injection of adherent cells into hamsters produces tumors with histological features of reticulum cell sarcoma.
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