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  • Title: Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates.
    Author: Kamal A, Vijaya Bharathi E, Janaki Ramaiah M, Surendranadha Reddy J, Dastagiri D, Viswanath A, Sultana F, Pushpavalli SN, Pal-Bhadra M, Juvekar A, Sen S, Zingde S.
    Journal: Bioorg Med Chem Lett; 2010 Jun 01; 20(11):3310-3. PubMed ID: 20444601.
    Abstract:
    A series of novel anthranilamide linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates were prepared and evaluated for their anticancer activity. The effects of three promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These promising compounds showed the characteristic features of apoptosis like enhancement in the levels of p53 and activation of caspase-3.
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