These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The effects of home-cage access to a sweet solution on the discriminative stimulus effects of cocaine.
    Author: Kohut SJ, Riley AL.
    Journal: Behav Pharmacol; 2010 May; 21(3):241-5. PubMed ID: 20445440.
    Abstract:
    This study assessed whether access to a sweet solution in the home cage could change sensitivity to cocaine, using a drug discrimination procedure. Rats were trained to discriminate 10 mg/kg cocaine from saline. After acquisition, rats were tested with a cumulative dose-response procedure (0-18 mg/kg) for 12 consecutive days. The 12 test days consisted of three 4-day cycles. The first cycle obtained a baseline of responding. During the second cycle, rats were given access to a bottle containing either a glucose/saccharin solution (G+S) or distilled water (dH2O) in addition to having free access to water in their home cage. During the final cycle, the G+S or dH2O bottle was removed. Discriminative control in the first cycle did not differ between pre-G+S and pre-dH2O. When the second bottle was presented, median effective dose values (ED50s) for cocaine in animals with access to G+S were higher than baseline, whereas the ED50s for cocaine in animals that received dH2O remained unchanged. During the final cycle when G+S was removed, ED50 values again did not differ after dH2O but remained increased for the rats with previous access to the G+S solution. Our data suggest that rats were less sensitive to the cocaine cue when a sweet solution was available in the home cage.
    [Abstract] [Full Text] [Related] [New Search]