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  • Title: Human monocyte heterogeneity--a nephrological perspective.
    Author: Rogacev KS, Heine GH.
    Journal: Nephrol Ther; 2010 Jul; 6(4):219-25. PubMed ID: 20447885.
    Abstract:
    Monocytes are key components of the innate immune system and are circulating precursors of tissue macrophages. Phenotypically and functionally, monocytes are a heterogeneous leukocyte subset. Based on the expression of CD14 and CD16, three human monocyte subsets can be distinguished: CD14++CD16-, CD14++CD16+ and CD14(+)CD16+ monocytes. The latter two subsets are often summarized as CD16+ monocytes. As these CD16+ cells are expanded in inflammatory conditions including end-stage renal disease, they have traditionally been termed proinflammatory monocytes, which is in contrast to murine monocyte nomenclature. More, each dialysis session induces a transient CD16+ monocytopenia.. In end-stage renal disease, both higher predialytic counts of CD16+ monocytes, and dialysis-induced CD16+ monocyte kinetic are predictors of cardiovascular outcome. So far, the functional differences of monocyte subsets and their pathophysiological role are still insufficiently understood.
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