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  • Title: BiliChek transcutaneous bilirubin meter overestimates serum bilirubin as measured by the Doumas reference method.
    Author: Karon BS, Wickremasinghe AC, Lo SF, Saenger AK, Cook WJ.
    Journal: Clin Biochem; 2010 Aug; 43(12):1009-12. PubMed ID: 20451510.
    Abstract:
    OBJECTIVES: To determine the relationship between BiliChek TcB (Respironics, Marietta GA) and Doumas reference serum or plasma total bilirubin (TSB). DESIGN AND METHODS: Pooled samples with values assigned by the Doumas reference method were used to establish the relationship between a local laboratory and reference Doumas TSB. We then established the relationship between TcB and TSB in the 3 months before and after reassignment of calibrator setpoints undertaken to match the local laboratory to Doumas reference bilirubin values. RESULTS: Before calibrator setpoint reassignment TSB as measured in our laboratory overestimated Doumas reference bilirubin. After calibrator adjustment laboratory TSB was within 1.7-6.8 micromol/L (0.1-0.4 mg/dL) of Doumas reference values. Mean bias between BiliChek TcB and TSB was 42.8+/-22.2 micromol/L (2.5+/-1.3mg/dL) (n=94) before and 49.6+/-22.2 micromol/L (2.9+/-1.3mg/dL) (n=115) after calibration adjustment. CONCLUSIONS: BiliChek TcB significantly overestimates TSB as measured by the Doumas reference method.
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