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  • Title: Red cell membrane during erythropoietin therapy in hemodialysis and in hemodiafiltration.
    Author: Icardi A, Paoletti E, Traverso GB, Sarchi C, Cappelli G, Molinelli G.
    Journal: Int J Artif Organs; 1991 Mar; 14(3):147-9. PubMed ID: 2045188.
    Abstract:
    This study assessed the effect of recombinant human erythropoietin (r-HuEPO) on red cell membrane behaviour in patients undergoing hemodialysis (HD) and hemodiafiltration (HDF). We studied erythrocyte osmotic fragility (EOF), mechanical fragility (EMF) and deformability (ED) before and after r-HuEPO therapy in patients on conventional dialysis treatment with a cuprophan membrane and in subjects undergoing HDF with a polyacrylonitrile membrane. Non-uremic, non-anemic subjects were enrolled as controls. Red cell membrane defects were more evident in HD than in HDF; r-HuEPO seemed to improve deformability in both groups compared to controls (p less than 0.005) possibly through the great production of red cells during this therapy.
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