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  • Title: Singly and doubly labeled base-discriminating fluorescent oligonucleotide probes containing oxo-pyrene chromophore.
    Author: Bag SS, Kundu R, Matsumoto K, Saito Y, Saito I.
    Journal: Bioorg Med Chem Lett; 2010 Jun 01; 20(11):3227-30. PubMed ID: 20452214.
    Abstract:
    We have developed new oxo-pyrene labeled fluorescent nucleoside, (Oxo-Py)U which showed a strong fluorescence dependency on solvent polarity at long wavelength. The designed singly and doubly (Oxo-Py)U labeled fluorescent oligonucleotide probes were found highly efficient for the discrimination of A and consecutive AA bases of target DNA opposite to the labeled base via generation of enhanced fluorescence signal.
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