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  • Title: Characteristics of No-go-P300 component during somatosensory Go/No-go paradigms.
    Author: Nakata H, Sakamoto K, Kakigi R.
    Journal: Neurosci Lett; 2010 Jul 12; 478(3):124-7. PubMed ID: 20452400.
    Abstract:
    The present study investigated one of the characteristics of No-go-related brain activity during somatosensory Go/No-go paradigms, by manipulating the stimulus site and response hand. Somatosensory event-related potentials (ERPs) were recorded in ten right-handed subjects. Electrical stimulation was delivered to the second and fifth digit of one hand, and the subjects had to respond to a Go stimulus by pushing a button with the thumb contralateral to the stimulated side as quickly as possible. We focused on the peak amplitude and latency of Som-Go-P300 (P300 evoked by somatosensory Go stimuli) and Som-No-go-P300 (P300 evoked by somatosensory No-go stimuli) components. The amplitude of Som-No-go-P300, which is very similar to No-go-P300 components following visual and auditory stimulation, was significantly larger than that of Som-Go-P300 at fronto-central electrodes, indicating 'anteriorization' of the No-go-P300. The amplitude of Som-No-go-P300 was significantly larger in right than left hemispheres during right hand response conditions, but this difference was not found under left hand conditions. In addition, the difference in amplitude between Som-Go- and Som-No-go-P300, which is frequently described as 'the Go/No-go effect' on P300, was significant in the left hemisphere under right hand response conditions, whereas a significant effect was found in both the left and the right hemispheres under left hand response conditions. Our findings suggested that the anteriorization of No-go-P300 was independent of stimulus modalities such as visual, auditory, and somatosensory, and the amplitude of No-go-P300 and Go/No-go effects on P300 was affected by the response hand.
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