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  • Title: Role of collapsin response mediator protein-2 in neurite outgrowth of PC12 cells.
    Author: Bork K, Karbe Y, Pollscheit J, Glaubitz N, Nöhring S, Horstkorte R.
    Journal: Neuroreport; 2010 Jun 23; 21(9):641-5. PubMed ID: 20453694.
    Abstract:
    Collapsin response mediator proteins (CRMPs) are involved in cell differentiation and axonal growth. In this study, we investigated neurite outgrowth and the expression of CRMP-2 in PC12 cells. Nondifferentiated PC12 cells hardly express CRMP-2, but the expression of CRMP-2 increases with neurite outgrowth. We established a stable CRMP-2-overexpressing PC12 cell line and found that PC12 cells, which constitutively overexpress CRMP-2, were unable to extend neurites after stimulation with the nerve growth factor or the neural cell adhesion molecule, a procedure that promotes neurite outgrowth in untransfected cells. In contrast, a PC12 cell line deficient in CRMP-2 extends neurites after the stimulation of nerve growth factor or neural cell adhesion molecule.
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