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  • Title: Zinc sulphate therapy for Wilson's disease after acute deterioration during treatment with low-dose D-penicillamine.
    Author: Veen C, van den Hamer CJ, de Leeuw PW.
    Journal: J Intern Med; 1991 Jun; 229(6):549-52. PubMed ID: 2045766.
    Abstract:
    A 30-year-old woman with Wilson's disease was treated with low-dose D-penicillamine. After 12 days, treatment was changed to zinc sulphate because of severe neurological deterioration. The patient subsequently improved within a few days. During a follow-up period of 20 months, the effectiveness of therapy was evaluated by measuring copper and zinc levels in plasma and urine, and by 64Cu-loading tests. We conclude that sulphate therapy may be a satisfactory alternative, even when rapid deterioration occurs in the early stages of D-penicillamine treatment.
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