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  • Title: A U-tetrad stabilizes human telomeric RNA G-quadruplex structure.
    Author: Xu Y, Ishizuka T, Kimura T, Komiyama M.
    Journal: J Am Chem Soc; 2010 Jun 02; 132(21):7231-3. PubMed ID: 20459096.
    Abstract:
    Telomeric repeat-containing RNA is a new noncoding RNA molecule recently discovered in mammalian cells. Here we report the structural features of human telomere RNA r(UAGGGU) in the presence of K(+) and Na(+). We demonstrated for the first time that a novel U-tetrad is formed at the 3' end of a parallel human telomeric RNA G-quadruplex. The U-tetrad dramatically stabilizes human telomeric RNA G-quadruplex structure, leading to an increase in melting temperature (T(m)) of 29 degrees C. The U-tetrad-stabilized telomeric RNA G-quadruplex structure adds considerably to our understanding of the diversity of RNA G-quadruplex architectures. It shows that the structure of base "quartets" is important in RNA assembly. The structural information will be invaluable for understanding the function of human telomere RNA.
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