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  • Title: [Feedback control of depth of anesthesia during propofol administration. Bispectral index as the controlled variable].
    Author: Janda M, Bajorat J, Simanski O, Kähler R, Pohl B, Nöldge-Schomburg GF, Hofmockel R.
    Journal: Anaesthesist; 2010 Jul; 59(7):621-7. PubMed ID: 20461346.
    Abstract:
    BACKGROUND: The objective of this study was to evaluate the performance of a new system for closed-loop control of propofol administration using the bispectral index (BIS) under total intravenous anesthesia in the index values of middle-to-deep depth of anaesthesia. METHODS: In this study 20 adult patients anesthetized with propofol and remifentanil were investigated. The propofol infusion was carried out using a fuzzy-PD+I controller with a target BIS value of 40. RESULTS: Closed-loop control was able to provide maintenance of anesthesia and adequate operating conditions for all patients. The following quality control criteria were calculated: median performance error (MDPE; 0.16%, SD +/-1.4%), median absolute performance error (MDAPE; 6.9%, SD +/-2.8%) and wobble (6.8%, SD +/-2.5%). CONCLUSION: The present study showed the clinical feasibility of the controller compared to existing devices regarding a high level of quality criteria of a model with an implemented fuzzy-PD+I structure controlling depth of hypnosis.
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