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  • Title: Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis.
    Author: Dorr MB, Nelson AL, Mayer PR, Ranganath RP, Norris PM, Helzner EC, Preston RA.
    Journal: Fertil Steril; 2010 Nov; 94(6):2365-8. PubMed ID: 20466363.
    Abstract:
    In this open-label, randomized, multiple-dose, two-treatment crossover study, 24 postmenopausal women with moderate to severe atrophic vaginitis received 0.3 mg conjugated estrogens daily for 14 days: 7 days orally (0.3 mg tablet) and 7 days vaginally (0.5 g cream). Steady-state plasma concentrations of E2 and estrone were one-third lower after vaginal versus oral administration of conjugated estrogens.
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