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  • Title: Serum angiopoietin-1 level is increased in patients with Behçet's disease.
    Author: Choe JY, Park SH, Kim SK.
    Journal: Joint Bone Spine; 2010 Jul; 77(4):340-4. PubMed ID: 20471887.
    Abstract:
    OBJECTIVE: Angiogenesis may be involved in the pathogenesis of Behçet's disease (BD). Some angiogenic factors such as vascular endothelial growth factor, monocyte chemoattractant protein-1, and endothelin-1 are significantly associated with BD. Here, we investigate whether Angiopoietin contributes to disease activity and clinical manifestations of BD. METHODS: We recruited 59 consecutive patients with BD and sex- and age-matched 65 healthy control subjects for this study. We reviewed data regarding clinical features, erythrocyte sediment rate (ESR), and C-reactive protein (CRP) at the time of enrollment. Serum angiopoietin-1 and angiopoietin-2 were estimated by enzyme-linked immunosorbent assay. Statistical analyses were performed using the Student t test and Pearson's correlation coefficient analysis. RESULTS: Levels of serum angiopoietin-1 are significantly increased in BD patients compared to controls (284.5+/-101.2 ng/ml of BD vs 237.1+/-76.4 ng/ml of controls, p=0.012). However, serum angiopoietin-2 levels are similar in both groups (974.2+/-679.3 pg/ml of BD vs 858.3+/-535.3 pg/ml of controls, p=0.562). Serum angiopoietin-1 expression is significantly elevated in patients with skin lesions (p=0.025) and positively correlated with disease duration (r=0.320, p=0.015). ESR levels are closely associated with serum angiopoietin-2 (r=0.306, p=0.018). CONCLUSION: Angiopoiein-1 expression is enhanced in BD patients compared to controls. This preliminary study identifies that angiopoietin-1 may play an important role in the pathogenesis of BD.
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