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  • Title: Separation of cis-beta-lactam enantiomers by capillary electrophoresis using cyclodextrin derivatives.
    Author: Németh K, Varga E, Iványi R, Szemán J, Visy J, Jicsinszky L, Szente L, Forró E, Fülöp F, Péter A, Simonyi M.
    Journal: J Pharm Biomed Anal; 2010 Nov 02; 53(3):382-8. PubMed ID: 20472380.
    Abstract:
    Chiral separation of 19 pairs of cis-beta-lactam (BL) stereoisomers of pharmacological importance was examined by capillary electrophoresis using cyclodextrin (CD) derivatives. In order to select the most effective conditions separating the highest number of stereoisomers of BLs, single carboxymethyl alpha-, beta- and gamma-, as well as sulfobutyl beta-CD derivatives were applied. Additionally, carboxymethyl and sulfobutyl beta-CD derivatives complemented with neutral beta-CD derivatives as dual CD systems were tested. Both the composition and concentration of applied selectors and the pH of background electrolyte were selected. In single systems the structural characteristics of BLs and the complex forming affinity were correlated. Most BLs provided optimal complexation with beta-CD derivatives. In conclusion, the efficiency of combining sulfobutyl-beta-CD and permethylated beta-CD was superior to other single and dual CD systems applied. This method successfully separated each pair of stereoisomers investigated.
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