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  • Title: A highly selective fluorescent probe for detection of biological samples thiol and its application in living cells.
    Author: Zuo QP, Li B, Pei Q, Li Z, Liu SK.
    Journal: J Fluoresc; 2010 Nov; 20(6):1307-13. PubMed ID: 20473559.
    Abstract:
    Probe 1 was designed and synthesized as a new fluorescent molecular probe for thiols in PBS buffer at physiological condition. This fluorescent molecular probe consists of a thiol reaction moiety bound to a coumarin fluorophore. Its fluorescence quantum yield is low, but a drastic enhancement of fluorescence intensity was observed in the presence of thiols. Possible interference with other analytes was examined. Probe 1 displays a highly selective fluorescent enhancement with thiols, and the probe was successfully applied to thiols determination in intracellular, in human urine and blood samples.
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