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  • Title: X-linked chronic granulomatous disease with voriconazole-induced photosensitivity/ photoaging reaction.
    Author: Frisch S, Askari SK, Beaty SR, Burkemper CN.
    Journal: J Drugs Dermatol; 2010 May; 9(5):562-4. PubMed ID: 20480802.
    Abstract:
    Due to the mutations in the nicotinamide dinucleotide phosphate (NADPH) oxidase complex in X-linked chronic granulomatous disease (CGD), the phagocytic activity in these patients is curtailed by a dysfunctional respiratory burst. This can lead to life-threatening bacterial and fungal infections. The prognosis for patients with CGD has dramatically improved with the advent of effective prophylactic drugs targeting catalase-positive bacteria, opportunistic Gram-negative bacteria and fungi. Voriconazole, a second-generation triazole, is a commonly used agent for prophylaxis in this population. The authors report a case of photoaging and photosensitivity reaction associated with voriconazole exposure in a 10-year-old boy with X-linked CGD. With broad-spectrum sunscreen, topical steroids, and discontinuation of voriconazole, the patient showed significant improvement.
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