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  • Title: Binding of botulinum type Cl, D and E neurotoxins to neuronal cell lines and synaptosomes.
    Author: Yokosawa N, Tsuzuki K, Syuto B, Fujii N, Kimura K, Oguma K.
    Journal: Toxicon; 1991; 29(2):261-4. PubMed ID: 2048142.
    Abstract:
    Clostridium botulinum 125I-labeled Cl neurotoxin bound to NG108 hybridoma cell line. Unlabeled type Cl neurotoxin inhibited the binding of the labeled Cl toxin but neither types D nor E toxin. 125I-labeled type D neurotoxin bound to rat brain synaptosomes but did not bind to NG108 cells. It is suggested that receptors for types C and D or E toxins on neuronal cell membranes are different.
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