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  • Title: Reduction of different inflammatory cell types of the innate immune system in psoriatic skin during etanercept treatment.
    Author: de Groot M, Teunissen MB, Picavet DI, de Rie MA, Bos JD.
    Journal: Exp Dermatol; 2010 Aug; 19(8):754-6. PubMed ID: 20482616.
    Abstract:
    To investigate whether specific markers for innate immunity would diminish with successful treatment in psoriasis, we analyzed lesional and non-lesional skin biopsies taken from patients with moderate to severe psoriasis during 12 weeks of treatment with etanercept in correlation with the clinical response. In the clinical responders (PASI reduction >50%), all markers (CD3, CD68, CD161, elastase, BDCA-2, TNF-alpha) showed a decline during treatment, indicating a pivotal role for innate immunity in the pathogenesis of psoriasis.
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