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  • Title: [Fatal pneumonitis due to oseltamivir-resistant new influenza A(H1N1) in the case of an intensive care patient].
    Author: Aardema H, Tulleken JE, van den Biggelaar RJ, Wolters BA, de Jager CM, Boucher CA, Riezebos-Brilman A.
    Journal: Ned Tijdschr Geneeskd; 2010; 154():A1634. PubMed ID: 20482913.
    Abstract:
    A 58-year-old man was submitted to our intensive care ward with respiratory failure due to pneumonitis. He had previously been treated for non-Hodgkin lymphoma by autologous stem cell transplantation, as a result of which bone marrow function was reduced. Further analysis showed infection with new influenza A(H1N1); typing revealed an oseltamivir-resistant subpopulation (H275Y). The patient was treated with oseltamivir and intravenously with zanamivir, but died of respiratory disease progression. This is the first published case of oseltamivir-resistant new influenza A(H1N1) infection in the Netherlands.
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