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  • Title: Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones as potent antimicrobial agent for human and plant pathogens.
    Author: Arumugam N, Raghunathan R, Shanmugaiah V, Mathivanan N.
    Journal: Bioorg Med Chem Lett; 2010 Jun 15; 20(12):3698-702. PubMed ID: 20483609.
    Abstract:
    Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones ring systems has been achieved by intermolecular 1,3-dipolar cycloaddition reaction of bicyclic nitrone with unusual dipolarophiles, arylidene chromanones/tetralones under different reaction conditions. The synthesized compounds were evaluated for antimicrobial activities. It was observed that two of the synthesized compounds exhibited relatively good antibacterial and antifungal activities.
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