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  • Title: Activity and enantioselectivity of the hydroxynitrile lyase MeHNL in dry organic solvents.
    Author: Paravidino M, Sorgedrager MJ, Orru RV, Hanefeld U.
    Journal: Chemistry; 2010 Jul 05; 16(25):7596-604. PubMed ID: 20486110.
    Abstract:
    Water concentration affects both the enantioselectivity and activity of enzymes in dry organic media. Its influence has been investigated using the hydrocyanation of benzaldehyde catalyzed by hydroxynitrile lyase cross-linked enzyme aggregate (MeHNL-CLEA) as a model reaction. The enzyme displayed higher enantioselectivity at higher water concentration, thus suggesting a positive effect of enzyme flexibility on selectivity. The activity increased on reducing the solvent water content, but drastic dehydration of the enzyme resulted in a reversible loss of activity.
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