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  • Title: Antifungal therapies in murine disseminated phaeohyphomycoses caused by Exophiala species.
    Author: Calvo E, Pastor FJ, Guarro J.
    Journal: J Antimicrob Chemother; 2010 Jul; 65(7):1455-9. PubMed ID: 20488983.
    Abstract:
    OBJECTIVES: We have evaluated the efficacy of posaconazole, itraconazole and amphotericin B in murine models of disseminated infection caused by Exophiala spp. METHODS: Immunosuppressed mice were treated with posaconazole at 10, 20 or 40 mg/kg/day orally (po), amphotericin B at 1.5 mg/kg/day intraperitoneally (ip) or itraconazole at 50 mg/kg/day po. Treatment began 1 day after infection and continued for 7 days post-infection. Two strains of each of the three most relevant clinical species, i.e. Exophiala dermatitidis, Exophiala oligosperma and Exophiala xenobiotica, were tested. RESULTS: Posaconazole showed the highest efficacy in mice infected with E. dermatitidis, the only species that showed a high neurotropism, while the three drugs showed a similarly good activity against E. oligosperma and E. xenobiotica infections. CONCLUSIONS: The results suggest that posaconazole may have a clinical role in the treatment of disseminated infections caused by Exophiala species, especially in those with CNS invasion.
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