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  • Title: Antimycotic effectiveness against dermatophytes: comparison of two in vitro tests.
    Author: Galuppi R, Gambarara A, Bonoli C, Ostanello F, Tampieri MP.
    Journal: Vet Res Commun; 2010 Jun; 34 Suppl 1():S57-61. PubMed ID: 20490661.
    Abstract:
    Seven antimycotic drugs (econazole, enilconazole, fluconazole, griseofulvin, itraconazole, ketoconazole, and miconazole) were tested against 36 dermatophyte strains (19 M. canis, 7 T. mentagrophytes, 5 M. gypseum, 2 M. cookei, 1 T. rubrum, 1 T. ajelloi, and 1 T. terrestre) isolated from animals, humans, and the environment. Two in vitro methods were compared: a micro-dilution test based on the CLSI M38-A method, and a disk-diffusion test. Fluconazole was not effective in vitro against the dermatophytes. Econazole and enilconazole were the most effective. Thirteen strains were griseofulvin-resistant. The correlation between the two methods was statistically significant for enilconazole, griseofulvin, itraconazole, and miconazole.
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