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  • Title: Synthesis of some 2-benzoxazolinone derivatives and their analgesic properties.
    Author: Erdogan H, Debaert M, Cazin JC.
    Journal: Arzneimittelforschung; 1991 Jan; 41(1):73-6. PubMed ID: 2049116.
    Abstract:
    In this study, eight new 1-(2-benzoxazolinone-6-yl)-2-(4-arylpiperazine-1-yl)ethanol and -propanol derivatives have been prepared. Their structures have been elucidated by IR- and 1H-NMR-spectra and by elementary analysis. The analgesic activities of these compounds, using modified Koster's test have been investigated. 1-(5-Chloro-3-methyl-2-benzoxazolone-6-yl)-2-[4-(2-methoxyphenyl)p iperazine-1- yl]ethanol has been found more active than O-acetyl-salicylic acid, respectively.
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