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  • Title: Fluorescent ratiometric MFC probe sensitive to early stages of alpha-synuclein aggregation.
    Author: Yushchenko DA, Fauerbach JA, Thirunavukkuarasu S, Jares-Erijman EA, Jovin TM.
    Journal: J Am Chem Soc; 2010 Jun 16; 132(23):7860-1. PubMed ID: 20491471.
    Abstract:
    We introduce a sensor molecule, AS140-MFC, consisting of a covalent adduct of an Ala-to-Cys mutant of alpha-synuclein with the 3-hydroxychromone dual emission dye MFC. We show that the AS140-MFC construct is a multiparametric fluorescent probe suitable for the continuous monitoring of protein aggregation and is sensitive to the early and intermediate stages of alpha-synuclein aggregation, a process associated with Parkinson's disease.
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