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  • Title: Diversity-oriented synthesis of disubstituted alkenes using masked silanols.
    Author: Sore HF, Blackwell DT, Macdonald SJ, Spring DR.
    Journal: Org Lett; 2010 Jun 18; 12(12):2806-9. PubMed ID: 20491504.
    Abstract:
    The regio- and stereoselective synthesis and subsequent Hiyama cross coupling of pentafluorophenyldimethylvinylsilanes has been developed, thus providing a convenient and robust method for the diversity-oriented synthesis of (E)-, (Z)- and alpha-disubstituted alkenes from terminal alkynes. Pentafluorophenyldimethylvinylsilanes undergo cross-coupling reactions with excellent selectivity and in good yields, offering an attractive alternative to existing masked silanols.
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