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  • Title: The effects of cimetidine and ranitidine on the pharmacokinetics of cifenline.
    Author: Massarella JW, Defeo TM, Liguori J, Passe S, Aogaichi K.
    Journal: Br J Clin Pharmacol; 1991 Apr; 31(4):481-3. PubMed ID: 2049259.
    Abstract:
    Twelve healthy subjects completed an open single dose study to evaluate the effect of co-administration of cimetidine and ranitidine on the pharmacokinetics of cifenline. Each subject received a single 160 mg dose of cifenline alone, in combination with cimetidine (300 mg four times daily), and with ranitidine (150 mg twice daily). The H2-receptor antagonists were given with breakfast 1 h prior to cifenline dosing and continuing for 48 h. Co-administration of cimetidine significantly increased Cmax (27%) and AUC (44%) and prolonged the half-life (30%) of cifenline. There were no differences in these parameters when ranitidine was co-administered with cifenline. The results of this study suggest that cimetidine, but not ranitidine, lowers the clearance of cifenline by inhibition of hepatic oxidative metabolism.
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