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  • Title: Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia.
    Author: Kapetanovic R, Jouvion G, Fitting C, Parlato M, Blanchet C, Huerre M, Cavaillon JM, Adib-Conquy M.
    Journal: Microbes Infect; 2010 Sep; 12(10):759-67. PubMed ID: 20493961.
    Abstract:
    Staphylococcus aureus is the most commonly found Gram-positive bacterium in patients admitted in intensive-care units, causing septicaemia or pneumonia. In this work, we investigated the role of NOD2 in S. aureus-induced pneumonia. We found that the absence of NOD2 affected weight loss and recovery speed. Nod2-/- mice showed a reduced lung inflammation in comparison to wild-type animals, with lower presence of cytokines in broncho-alveolar lavage fluids and reduced recruitment of neutrophils. Furthermore, histological analysis of the lungs revealed less severe lesions in Nod2-/- mice at day 2 and day 7 post-infection. In conclusion, we demonstrated that NOD2 is not a crucial receptor to fight S. aureus-induced pneumonia, but that it contributes to the inflammatory response in the lungs. Interestingly, the absence of NOD2 led to a lesser inflammation and was finally beneficial for the animal recovery.
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