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  • Title: [Clinical and laboratory evaluation of efficiency of Helicobacter pylori eradication].
    Author: Drygina LB, Poiarkova NA, Sablin OA.
    Journal: Eksp Klin Gastroenterol; 2010; (2):27-31. PubMed ID: 20496805.
    Abstract:
    AIM: To assess the efficiency of eradication therapy in long-term period using the main signs of functional activity of gastric mucosa (gastrin-17, pepsinogen I, pepsinogen II) and serum antibodies to H. pylori. MATERIALS AND METHODS: 113 patients with chronic gastritis were examihed using clinical, endoscopic and laboratory-based methods of investigation, including GastroPanel Biohit, Finland. RESULTS: It was observed that after 12 month of successful eradication therapy the titer of IgG to H. pylori did not exceed 60 IU/l, with pepsinogen I and pepsinogen II cut-off values set under 150 microg/l and 15 microg/l respectively. CONCLUSION: The decrease of the titer of IgG to H. pylori and concentrations of pepsinogen I and II can be used as criteria of successful eradication therapy in long-term period.
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